Developmental refinement of inhibitory sound-localization circuits
نویسندگان
چکیده
منابع مشابه
Evolution of mammalian sound localization circuits: A developmental perspective.
Localization of sound sources is a central aspect of auditory processing. A unique feature of mammals is the smooth, tonotopically organized extension of the hearing range to high frequencies (HF) above 10kHz, which likely induced positive selection for novel mechanisms of sound localization. How this change in the auditory periphery is accompanied by changes in the central auditory system is u...
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Establishing precise neuronal connections is crucial for normal brain function. In many parts of the brain, this is accomplished by refining initially diffuse neuronal connections during development. In contrast to our understanding of the mechanisms by which excitatory connections are refined, the refinement of inhibitory circuits is poorly understood. In this thesis, I investigated the refine...
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Collybistin is a brain-specific guanine nucleotide exchange factor (GEF) that is crucial for the postsynaptic accumulation of gephyrin and γ-aminobutyric acid A receptors (GABA(A) Rs) at a specific subset of inhibitory synapses. Our understanding of the in vivo function of collybistin has been hampered by lack of information about the synaptic localization of this protein in brain circuits. Her...
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The principles of human sound localization imply binaural (interaural level and time difference) as well as monaural cues. The latter are captured by the head-related transfer functions (HRTFs), which describe the direction-dependent, spectral shaping of the incident sound wave, and can be exploited to determine the direction. In this paper an accurate talker localization strategy in the horizo...
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Sound-source localization systems typically comprise free-field microphone arrays. In nature, directional acoustic sensing evolved to rely on diffraction about the head with only two ears. For localization, the brain uses the resultant frequency-dependent acoustic phase and intensity differences between the two ears. We conceive a biomimetic artificial head with microphones placed on its surfac...
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ژورنال
عنوان ژورنال: Trends in Neurosciences
سال: 2005
ISSN: 0166-2236
DOI: 10.1016/j.tins.2005.04.007